The game is set some time after the original Epic Mickey. The Mad Doctor, whom Mickey defeated in the first game, mysteriously returns to the Wasteland, despite having been supposedly blown up in the first game. He claims to have realised the error of his ways, and offers to work with Oswald The Lucky Rabbit and the other residents of Wasteland to repair the damage recently caused by earthquakes in order to make amends. Giving him the benefit of the doubt, Oswald agrees. However, not long after accepting the Mad Doctor’s help, the Wasteland begins to suffer even more damage than before.
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